Explore https://ligaz.bet/ Options
Explore https://ligaz.bet/ Options
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The undifferentiated nucleotide specificities of particular archaeal ligases have tantalizing implications for enzyme evolution as well as attainable utilization of ADP as being a substrate by ancestors of contemporary DNA ligases. The ability of some archaeal ligases to employ ATP and NAD+ or ATP and ADP as substrates might be stated if they identified just the ADP element frequent to all three nucleotides.
; with DNA omitted) were superimposed with regard for their NTase domains and afterwards offset laterally to reveal the large motion on the OB domain activated by nick recognition.
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(eighteen) have conducted a virtual screen for small molecules that might dock into your N-terminal DBD of HuLig1, a website conserved in all mammalian DNA ligases. They thereby discovered compounds that (i) inhibited nick sealing by human ligases in vitro
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